The description of musical instruments in terms of Greek origin (zither, psaltery, and symphony) has led numerous theologians to consider that the composition of the book of Daniel took place in the first century B.C. Nevertheless, it is plausible that such instruments were part of Nebuchadnezzar's orchestra, that is, in Babylon, in the sixth century B.C.? This study seeks to demonstrate, through the analysis of historical and archaeological aspects, that it is posible that similar instruments existed in Babylon at that time. First, because there is the possibility that commercial relations existed between Mesopotamia and Greece. Second, because the use of music and musical instruments identical or similar to those mentioned in Daniel 3 in Mesopotamia dates back to its earliest periods.